Each house in the city's Lower Ninth Ward, which was deluged by flooding in 2005, will be built on stilts.
"This is really an adopt-a-house campaign," said Pitt, who hoped that wealthy individuals, church groups and businesses would make pledges of $150,000 (£72,750), the sum needed to give a family a new home.
The buildings, which have been designed by a team of 13 architects, have been planned to environmentally-friendly specifications.
Brad Pit and partner Angelina Jolie own a mansion in New Orleans' French Quarter. Jolie and the couple's son Maddox accompanied Pitt as he campaigned for further funds on The Today Show on US network NBC. Link